There is considerable interest in identifying the basic mechanisms by which dexamethasone
alters ion transport across the adult alveolar epithelium. Herein, we incubated synchronized …

cAMP and dexamethasone are known to modulate Na+ transport in epithelial cells. We
investigated whether dibutyryl cAMP (DBcAMP) and dexamethasone modulate the mRNA …

Treating H441 cells with dexamethasone raised the abundance of mRNA encoding the
epithelial Na+ channel α-and β-subunits and increased transepithelial ion transport …

Alveolar hypoxia may impair sodium-dependent alveolar fluid transport and induce
pulmonary edema in rat and human lung, an effect that can be prevented by the inhalation of …

The recent immunopurification and cloning of various lung Na+ channel proteins has
provided the necessary tools to study Na+ transport at a fundamental level across a number …

In airway and renal epithelia, the glucocorticoid-mediated stimulation of amiloride-sensitive
Na+ transport is associated with increased expression of the epithelial Na+ channel α …

Alveolar fluid clearance in the developing and mature lungs is believed to be mediated by
some form of epithelial Na channels (ENaC). However, single-channel studies using …

Amiloride-sensitive Na+ channels are an important component of the Na+ reabsorption
pathway in a number of epithelia. Here we report the cloning and characterization of cDNAs …

The transport of Na+ through amiloride-sensitive sodium channels (ENaC) plays a major
role in the absorption of fluid across the pulmonary epithelium. The proteins forming the …

The amount of fluid covering the epithelium of the airways and alveolar space is modulated
by active transport of Na+ from the lumen through the apical membrane Na+ permeant ion …