The mammalian sperm genome is thought to lack substantial information for the regulation
of future expression after fertilization. Here, we show that most promoters in mouse sperm …

Histone modifications are fundamental epigenetic regulators that control many crucial
cellular processes. However, whether these marks can be passed on from mammalian …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

Trimethylation of histone H3 on lysine-4 (H3K4me3) is associated with gene-regulatory
elements, but its transcription-independent function in cell division is unclear. CxxC-finger …

Histone-modifying enzymes are required for cell identity and lineage commitment, however
little is known about the regulatory origins of the epigenome during embryonic development …

'Epigenetics' has been defined as the study of 'mitotically and/or meiotically heritable
changes in gene function that cannot be explained by changes in DNA sequence' …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

The different configurations of maternal and paternal chromatin, acquired during oogenesis
and spermatogenesis, have to be rearranged after fertilization to form a functional embryonic …

Transcriptional activation is controlled by chromatin, which needs to be unfolded and
remodeled to ensure access to the transcription start site (TSS). However, the mechanisms …

Heterochromatin assembly requires methylation of histone H3 lysine 9 (H3K9me) and
serves as a paradigm for understanding the importance of histone modifications in …