5-HT7 receptor antagonists generated antidepressant-like effects in animal model and the
involvement of the 5-HT7 receptor in other pathophysiological mechanisms such as …

We report the in vitro drug-likeness studies and in vivo pharmacological evaluation for a new
potent 5-HT 7 receptor antagonist MF-8 (5-(4-fluorophenyl)-3-(2-hydroxy-3-(4-(2 …

N1-Arylsulfonyl-3-piperazinyl indole derivatives were designed and identified as a novel
class of 5-HT6 receptors ligands. All the compounds have high affinity and antagonist …

Twenty-four compounds of 4-methoxy-N-[3-(4-substituted phenyl-piperazine-1-yl) propyl]
benzene sulfonamides and N-[3-(4-substituted phenyl-piperazine-1-yl) propyl] naphthyl …

A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the
pharmacophoric requirements of 5-HT3 receptor antagonist using ligand-based approach …

HT 7 receptor (5-HT 7 R) is a promising target for the treatment of depression and
neuropathic pain. 5-HT 7 R antagonists exhibited antidepressant effects, while the agonists …

HT 7 receptor (5-HT 7 R) agonists and antagonists have been reported to be used for
treatment of neuropathic pain and depression, respectively. In this study, as a novel scaffold …

New potent 5-HT 3 receptor antagonists have been designed from the naphthalimide moiety
and a quinuclidine heterocycle and the structure-activity relationships are discussed here on …

Novel arene-and quinolinesulfonamides were synthesized using different solutions and a
solid-support methodology, and were evaluated for their affinity for 5-HT1A, 5-HT2A, 5-HT6 …

A 5, 7-dichloro-3-phenyl-3-methyl-quinoline-2, 4-dione (11a) has been identified in a
random screen as a lead for 5-HT6 antagonist. During the lead optimization process, several …