• Introduction• Molecular profiling for cancer classification• Molecular profiling of cancer stem
cells‐Historical perspective: cancer stem cells in leukaemia‐Molecular profiling of brain …

The cancer stem cell (CSC) hypothesis is increasingly being accepted as a model to explain
for the functional heterogeneity that is commonly observed in solid tumors. According to this …

Published at www. cmaj. ca on Dec. 13, 2006. cant. If this view of human cancer continues to
gain experimental support, it is likely that our current strategies may have emphasized the …

Purpose: New understanding of cancer stem cell (CSC) biology continues to emerge due to
development of novel methods in genomics and proteomics. Analysis of nucleic acids (RNA …

Mounting evidence suggests that malignant tumors are initiated and maintained by a
subpopulation of cancerous cells with biological properties similar to those of normal stem …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

Biologically distinct populations of neoplastic stem cells have been identified in a variety of
human cancers, in which they are associated with the initial steps of tumorigenesis. The …

Accumulating evidence suggests that human cancers develop through a step-wise, but
nonlinear process of cellular diversification and evolution. Recent mutational analyses …

Evidence has accumulated that characterizes highly tumorigenic cancer cells residing in
heterogeneous populations. The accepted term for such a subpopulation is cancer stem …

Cancer is a complex disease involving hundreds of pathways and numerous levels of
disease progression. In addition, there is a growing body of evidence that the origins and …