The central nervous system requires the proper formation of exquisitely precise circuits to
function properly. These neuronal circuits are assembled during development by the …

▪ Abstract Despite considerable evidence that neuronal activity influences the organization
and function of circuits in the developing and adult brain, the molecular signals that translate …

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

The neurotrophins are best known for their ability to support neuronal survival and
differentiation, but a role in synapse formation and plasticity has recently emerged. For …

Neurotrophins were originally identified by their ability to promote the survival of developing
neurons. However, recent work on these proteins indicates that they may also influence the …

A number of recent results suggest that neurotrophins play an important role in early
development as well as in the later, activity-dependent processes important for the final …

While it has now been well accepted that neurotrophins play an important role in synapse
development and plasticity, the specific effects of each neurotrophin on different populations …

The neurotrophin hypothesis proposes that neurotrophins participate in activity-induced
modification of synaptic transmission. Increasingly, evidence indicates that the synthesis …

Neurotrophic factors are traditionally viewed as secretory proteins that regulate long-term
survival and differentiation of neurons. The role of neurotrophic factors in the structural …