Treatments in idiopathic pulmonary fibrosis: time for a more targeted approach?

S Mahendran, T Sethi - QJM: An International Journal of …, 2012 - academic.oup.com
Idiopathic pulmonary fibrosis (IPF) is a progressive age-related lung disease, the cause of
which is not been fully understood. IPF is a devastating disease with mortality worse than …

Treatment approach to connective tissue disease-associated interstitial lung disease

TM Wilson, JJ Solomon, MK Demoruelle - Current opinion in pharmacology, 2022 - Elsevier
Interstitial lung disease (ILD) is a common manifestation in connective tissue diseases
(CTD), such as rheumatoid arthritis (RA), systemic sclerosis (SSc), and inflammatory …

Patient-centered outcomes research in interstitial lung disease: an official American Thoracic Society research statement

KI Aronson, SK Danoff, AM Russell… - American journal of …, 2021 - atsjournals.org
Background: In the past two decades, many advances have been made to our
understanding of interstitial lung disease (ILD) and the way we approach its treatment …

Interstitial lung diseases

M Wijsenbeek, A Suzuki, TM Maher - The Lancet, 2022 - thelancet.com
Over 200 interstitial lung diseases, from ultra rare to relatively common, are recognised.
Most interstitial lung diseases are characterised by inflammation or fibrosis within the …

Drug discovery and development in idiopathic pulmonary fibrosis: challenges and opportunities

S Cruwys, P Hein, B Humphries, D Black - Drug Discovery Today, 2020 - Elsevier
IPF is a chronic disease characterized by progressive loss of lung tissue 1, 2, 3. Although
several risk factors have been described [4], the triggers and causes of IPF remain unknown …

Facts and promises on lung biomarkers in interstitial lung diseases

I Campo, M Zorzetto, F Bonella - Expert review of respiratory …, 2015 - Taylor & Francis
Interstitial lung diseases (ILDs) are a heterogeneous group of> 100 pulmonary disorders.
ILDs are characterized by an irreversible architectural distortion and impaired gas …

A contemporary practical approach to the multidisciplinary management of unclassifiable interstitial lung disease

CJ Ryerson, TJ Corte, JL Myers… - European …, 2021 - Eur Respiratory Soc
Fibrotic interstitial lung diseases (ILDs) frequently have nonspecific and overlapping clinical
and radiological features, resulting in∼ 10–20% of patients with ILD lacking a clear …

Biomarkers in progressive fibrosing interstitial lung disease: optimizing diagnosis, prognosis, and treatment response

WS Bowman, GA Echt, JM Oldham - Frontiers in Medicine, 2021 - frontiersin.org
Interstitial lung disease (ILD) comprises a heterogenous group of diffuse lung disorders that
commonly result in irreversible pulmonary fibrosis. While idiopathic pulmonary fibrosis (IPF) …

Targeted therapy in rheumatoid-arthritis-related interstitial lung disease

R Harrington, P Harkins, R Conway - Journal of Clinical Medicine, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic autoimmune multisystem inflammatory disease in
which lung involvement is the most common extra-articular manifestation. Parenchymal lung …

Emerging role of immune cells as drivers of pulmonary fibrosis

SE Mutsaers, T Miles, CM Prêle, GF Hoyne - Pharmacology & Therapeutics, 2023 - Elsevier
The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …