Labeling of plasma transferrin with gallium was investigated to determine whether the
gallium-transferrin complex could be effectively used as a macromolecular tracer in studies …

As a crucial step toward the understanding of the tumor localization of gallium, we have re-
investigated its binding and transport in blood. The studies were performed in vivo by …

The mechanism of radiogallium uptake into tumor in vivo has been investigated using the
canine transmissible venereal tumor (TVT) as a model. The blood clearance and uptake in …

MATERIALSAND METHODS Carrier-free 67Ga-citrate was purchased from Medi-Physics,
Chicago, IL. Iodine-l31 (ICN Radiochemicals, Irvine, CA) was labeled to human serum …

When injected at tracer levels into the blood, radiogallium as 67 Ga-citrate binds to, and is
transported to the site of the tumor by, transferrin. The process by which transferrin-bound …

DTPA,histamine,humanalbumin,transferrin,*and Page 1 In 1969, Edwards and Hayes (1) noted
that gal lium-67 accumulated in involved lymph nodes in Hodgkin's disease. Since then, Ga-67 …

Wesley R. Harris* and Vincent L. Pecoraro* 1 abstract: Gallium-67 is widely used as an
imaging agent for tumors and inflammatory abscesses. It is well established that Ga3+ …

Different gallium-transferrin-anion complexes (nitrilotriacetate, maleate, malonate and
oxalate) were investigated to determine the effect of such anion complexes on gallium-67 …

When injected at tracer levels into the blood, radiogallium binds to plasma transferrin and is
transported to the tumor tissue. The mechanism, however, by which this transferrin-bound …

If iv injected radiogallium does not firmly bind to circulating transferrin in plasma, the
transvascular transport of the radionuclide may be affected by diffusion of unbound …