Objective It has been debated whether the onset of knee osteoarthritis is initiated in cartilage
or subchondral bone. The purpose of this study was to clarify the effects of increasing or …

Objective Joint instability induced by anterior cruciate ligament (ACL) transection is
commonly considered as a predisposing factor for osteoarthritis (OA) of the knee; however …

Background: Joint instability has long been empirically recognized as a leading risk factor
for osteoarthritis. However, formal mechanistic linkage of instability to osteoarthritis …

Objective Progressive knee osteoarthritis (OA) is believed to result from local factors acting
in a systemic environment. Previous studies have not examined these factors concomitantly …

Joint instability and cartilage trauma have been previously studied and identified as key
mediators in the development of posttraumatic osteoarthritis (PTOA). The purpose of this …

Objective Abnormal joint instability contributes to cartilage damage and osteophyte
formation. We investigated whether controlling joint instability inhibited chronic synovial …

Medial meniscus destabilization (MMD) is a surgical insult technique for modeling
osteoarthritis (OA) by replicating chronic abnormal cartilage loading in animal joints in vivo …

OBJECTIVE: The pathogenesis of osteoarthritis (OA) includes cartilage degeneration,
synovial inflammation, and bone changes. Slowly, the sequence and inter-relationship of …

Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction,
subchondral bone sclerosis, and osteophyte formation. Subchondral bone stiffness has …

Background: The predictable outcome of the anterior cruciate ligament transection (ACLT)
canine model, and the similarity to naturally occurring osteoarthritis (OA) in humans, provide …