As a key step in next-generation risk assessment (NGRA), in vitro to in vivo extrapolation
(IVIVE) aims to mobilize a mechanism-based understanding of toxicology to translate …

With an increasing need to incorporate new approach methodologies (NAMs) in chemical
risk assessment and the concomitant need to phase out animal testing, the interpretation of …

During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

Chemical toxicity testing is moving steadily toward a human cell and organoid-based in vitro
approach for reasons including scientific relevancy, efficiency, cost, and ethical rightfulness …

Toxicokinetics (TK) is the endpoint that informs about the penetration into and fate within the
body of a toxic substance, including the possible emergence of metabolites. Traditionally …

High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new
approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro …

Humans are continually exposed to a vast number of chemicals that may enter the
environment through various pathways. Nevertheless, information on exposure and hazards …

Globally, industries and regulatory authorities are faced with an urgent need to assess the
potential adverse effects of chemicals more efficiently by embracing new approach …

While the first use of the term “Predictive Toxicology” was mainly focusing on in silico
approaches and applied almost synonymously to computational toxicology (Helma, 2005) it …

While the first use of the term “Predictive Toxicology” was mainly focusing on in silico
approaches and applied almost synonymously to computational toxicology (Helma, 2005) it …