Individuals differ widely in their ability to repair DNA damage, and DNA‐repair deficiency
may be involved in modulating cancer risk. In a case‐control study of 124 bladder‐cancer …

Bladder cancer is associated with tobacco smoking and occupational exposure. The repair
of DNA damage has a key role in protecting the genome from the insults of cancer-causing …

DNA repair efficiency varies among individuals, with reduced repair capacity as a risk factor
for various cancers. This variability could be partly explained by allelic variants for different …

Bladder cancer is the sixth most common cancer in the United States. The main identified
risk factor is cigarette smoking, which is estimated to contribute to up to 50% of new cases in …

Tobacco smoking and occupational exposures are the main known risk factors for bladder
cancer, causing direct and indirect damage to DNA. Repair of DNA damage is under genetic …

DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity
and may influence an individual's susceptibility to carcinogenesis. Single nucleotide …

In polygenic diseases, association studies look for genetic variation such as polymorphisms
in low penetrance genes, ie genes in interaction with environmental factors. DNA repair …

Polymorphisms in several DNA repair genes have recently been identified, but little is known
about their phenotypic significance. To determine whether variation in DNA repair genes is …

Study results of single nucleotide polymorphisms (SNPs) and cancer susceptibility are often
conflicting, possibly because of the analytic challenges of testing for multiple genetic and …

The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate
gene for cancer susceptibility. However, association studies on the XRCC3 polymorphisms …