Randomized clinical trials are the gold standard for evaluating interventions as randomized
assignment equalizes known and unknown characteristics between intervention groups …

Randomized clinical trials are the primary tool for evaluating new medical interventions.
Randomization provides for a fair comparison between treatment and control groups …

The Prevention and Treatment of Missing Data in Clinical Trials | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Background Randomized controlled trials almost always have some individuals with missing
outcomes. Inadequate handling of these missing data in the analysis can cause substantial …

Recent decades have brought advances in statistical theory for missing data, which,
combined with advances in computing ability, have allowed implementation of a wide array …

The aim of this review was to establish the frequency with which trials take into account
missingness, and to discover what methods trialists use for adjustment in randomised …

This book provides practical guidance for statisticians, clinicians, and researchers involved
in clinical trials in the biopharmaceutical industry, medical and public health organisations …

Background No methods directly address the impact of missing participant data for
continuous outcomes in systematic reviews on risk of bias. Methods We conducted a …

Objective: Missing data are ubiquitous in clinical trials, yet recent research suggests many
statisticians and investigators appear uncertain how to handle them. The objective is to set …

Background Missing outcome data is a threat to the validity of treatment effect estimates in
randomized controlled trials. We aimed to evaluate the extent, handling, and sensitivity …