[HTML][HTML] Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer
Cancer is a leading cause of death worldwide. Aberrant promoter hypermethylation of CpG
islands associated with tumor suppressor genes can lead to transcriptional silencing and …
islands associated with tumor suppressor genes can lead to transcriptional silencing and …
[HTML][HTML] Emerging role of different DNA methyltransferases in the pathogenesis of cancer
P Liu, F Yang, L Zhang, Y Hu, B Chen… - Frontiers in …, 2022 - frontiersin.org
DNA methylation is one of the most essential epigenetic mechanisms to regulate gene
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …
[HTML][HTML] DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy
J Zhang, C Yang, C Wu, W Cui, L Wang - Cancers, 2020 - mdpi.com
DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
Misregulation of the expression and activity of DNA methyltransferases in cancer
In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …
[HTML][HTML] Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors
Significant reprogramming of epigenome is widely described during pathogenesis of breast
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …
[HTML][HTML] DNA methyltransferases: a novel target for prevention and therapy
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …
agents, and the use of various therapeutic combinations, none of the available treatment …
DNMT1: catalytic and non-catalytic roles in different biological processes
KN Mohan - Epigenomics, 2022 - Taylor & Francis
DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …
Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications
DNA methylation is an important epigenetic mechanism that ensures correct gene
expression and maintains genetic stability. DNA methyltransferase 1 (DNMT1) is the primary …
expression and maintains genetic stability. DNA methyltransferase 1 (DNMT1) is the primary …
[HTML][HTML] DNA methyl transferase 1: regulatory mechanisms and implications in health and disease
S Dhe-Paganon, F Syeda, L Park - International journal of …, 2011 - ncbi.nlm.nih.gov
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function
DNA methylation is one of the principal epigenetic signals that participate in cell specific
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …