Aim: Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of
incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy …

Lauroyl-gemcitabine lipid nanocapsules (GemC 12-LNC) hydrogel, administered
intratumorally or perisurgically in the tumor resection cavity, increases animal survival in …

Glioblastoma (GBM) treatment includes, when possible, surgical resection of the tumor
followed by radiotherapy and oral chemotherapy with temozolomide, however recurrences …

The local delivery of chemotherapeutic agents is a very promising strategy for the treatment
of glioblastoma (GBM). Gemcitabine is a chemotherapeutic agent that has a different …

Glioblastoma (GBM) recurrences are inevitable, and mainly originate from residual tumor
cells and the presence of glioma stem cells (GSC) around the resection cavity borders. We …

Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders
and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a …

The objective of this work was to develop an implantable therapeutic hydrogel that will
ensure continuity in treatment between surgery and radiochemotherapy for patients with …

Glioblastoma multiforme (GBM), a prevalent brain cancer with high mortality, is resistant to
the conventional single-agent chemotherapy. In this study, we employed a combination …

Among central nervous system tumors, Glioblastoma (GBM) is the most common, aggressive
and neurological destructive primary brain tumor in adults. Standard care therapy for GBM …

Herein, an injectable formulation composed of a low molecular weight gelator (LMWG)
based hydrogel and drug-loaded polymeric nanocapsules (NCs) is described. The NCs …