There is considerable interest in the development of sequence-selective DNA drugs.
Chemical agents able to interfere with DNA topoisomerases-essential nuclear enzymes-are …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Topoisomerase I is an ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins as well as for indolocarbazole antibiotics such as …

Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and
some of them have clinical efficacy as antitumor or antibacterial drugs. Drugs which have as …

Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and
some of them have outstanding therapeutic efficacy in human cancer and infectious …

Topoisomerase I is an ubiquitous DNA cleaving enzyme and an important therapeutic target
in cancer chemotherapy for the camptothecins as well as for indolocarbazole antibiotics …

DNA-topoisomerases, a family of DNA-processing enzymes, represent the pharmacological
target of major clinically useful chemotherapeutic agents. These drugs essentially act by …

Triple helix‐forming oligonucleotides covalently linked to topoisomerase I inhibitors, in
particular the antitumor agent camptothecin, trigger topoisomerase I‐mediated DNA …

DNA topoisomerase II targeting agents such as etoposide and doxorubicin are well-
established cancer chemotherapeutic agents. Topotecan (Hycamtin) and irinotecan …

Inhibitors of topoisomerase I constitute a novel family of antitumor agents. The camptothecin
derivatives topotecan and irinotecan represent new weapons in our arsenal for battling …