Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Respiratory function decline and increase ofoxidative stress in mitochondria have
beenproposed as important contributors to humanaging. A wide spectrum of alterations in …

A wide spectrum of alterations in mitochondria and mitochondrial DNA (mtDNA) with aging
has been observed in animals and humans. These include (i) decline in mitochondrial …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Aging is a degenerative process that is associated with progressive accumulation of
deleterious changes with time, reduction of physiological function and increase in the …

Mitochondrial dysfunction is a central event in many pathologies and contributes as well to
age-related processes. However, distinguishing between primary mitochondrial dysfunction …

The mitochondrial theory of aging, a mainstream theory of aging which once included
accumulation of mitochondrial DNA (mtDNA) damage by reactive oxygen species (ROS) as …

Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox
messengers' in the regulation of intracellular signalling, whereas excess ROS may induce …

Aging is accompanied by a time-dependent progressive deterioration of multiple factors of
the cellular system. The past several decades have witnessed major leaps in our …

Introduction 3. The chemistry of reactive oxygen species (ROS) 4. Normal functions of ROS
5. Classes of macromolecules undergoing oxidative damage 6. Mitochondria as the major …