Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that
participate in many physiological functions. Receptors result from the assembly of five …

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

Neuronal nicotinic acetylcholine receptors (nAChRs) are an important class of ion channels
that have been associated with a number of neurological conditions. A great deal of …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Substantial progress in the identification of genes encoding for a large number of proteins
responsible for various aspects of neurotransmitter release, postsynaptic detection and …

Publisher Summary This chapter discusses advances in molecular design and therapies
associated with nicotinic acetylcholine receptors (nAChRs), which are members of the …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …

Nicotinic acetylcholine receptors (nAChRs) are a critical component of the brain's
cholinergic neurotransmission system that modulates important physiological processes and …

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …