A hallmark of M. tuberculosis infection is the ability of most (90–95%) healthy adults to
control infection through acquired immunity, in which antigen specific T cells and …

The intimate and persistent connection between Mycobacterium tuberculosis and its human
host suggests that the pathogen has evolved extensive mechanisms to evade eradication by …

Mycobacterium tuberculosis is a very successful pathogen that can survive and persist in the
human host in the face of a robust immune response. This immune response is sufficient to …

Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons
have latent infection, 8 million people develop active tuberculosis annually, and 2–3 million …

The continuing HIV/AIDS epidemic and the spread of multi-drug resistant Mycobacterium
tuberculosis has led to the perpetuation of the worldwide tuberculosis epidemic. While M …

A prerequisite for successful establishment of Mycobacterium tuberculosis in the host is its
ability to survive after internalization in alveolar macrophages that they encounter after …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

ABSTRACT A major impediment to tuberculosis (TB) vaccine development is the lack of
reliable correlates of immune protection or biomarkers that would predict vaccine efficacy …

Protective immunity against Mycobacterium tuberculosis (MTB) in animal models is based
on cell-mediated immunity (CMI), involving bi-directional interactions between T cells and …

Despite the overwhelming success of immunization in reducing, and even eliminating, the
global threats posed by a wide spectrum of infectious diseases, attempts to do the same for …