CD-CODE: crowdsourcing condensate database and encyclopedia
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …
High-throughput and proteome-wide discovery of endogenous biomolecular condensates
Phase separation inside mammalian cells regulates the formation of the biomolecular
condensates that are related to gene expression, signalling, development and disease …
condensates that are related to gene expression, signalling, development and disease …
Small molecule properties define partitioning into biomolecular condensates
SA Thody, HD Clements, H Baniasadi, AS Lyon… - BioRxiv, 2022 - biorxiv.org
Biomolecular condensates regulate cellular function by compartmentalizing molecules
without a surrounding membrane,. Condensate functions are believed to arise from the …
without a surrounding membrane,. Condensate functions are believed to arise from the …
Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets
X Niu, L Zhang, Y Wu, Z Zong, B Wang, J Liu… - MedComm, 2023 - Wiley Online Library
Biomolecular condensates are cellular structures composed of membraneless assemblies
comprising proteins or nucleic acids. The formation of these condensates requires …
comprising proteins or nucleic acids. The formation of these condensates requires …
Learning the chemical grammar of biomolecular condensates
HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
A framework for understanding the functions of biomolecular condensates across scales
AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates
Biomolecular condensates are implicated in core cellular processes such as gene
regulation and ribosome biogenesis. Although the architecture of biomolecular condensates …
regulation and ribosome biogenesis. Although the architecture of biomolecular condensates …
[HTML][HTML] Principles and functions of condensate modifying drugs
Biomolecular condensates are compartmentalized communities of biomolecules, which
unlike traditional organelles, are not enclosed by membranes. Condensates play roles in …
unlike traditional organelles, are not enclosed by membranes. Condensates play roles in …
Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …