CD-CODE: crowdsourcing condensate database and encyclopedia

N Rostam, S Ghosh, CFW Chow, A Hadarovich… - Nature …, 2023 - nature.com
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …

High-throughput and proteome-wide discovery of endogenous biomolecular condensates

P Li, P Chen, F Qi, J Shi, W Zhu, J Li, P Zhang, H Xie… - Nature Chemistry, 2024 - nature.com
Phase separation inside mammalian cells regulates the formation of the biomolecular
condensates that are related to gene expression, signalling, development and disease …

Small molecule properties define partitioning into biomolecular condensates

SA Thody, HD Clements, H Baniasadi, AS Lyon… - BioRxiv, 2022 - biorxiv.org
Biomolecular condensates regulate cellular function by compartmentalizing molecules
without a surrounding membrane,. Condensate functions are believed to arise from the …

Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets

X Niu, L Zhang, Y Wu, Z Zong, B Wang, J Liu… - MedComm, 2023 - Wiley Online Library
Biomolecular condensates are cellular structures composed of membraneless assemblies
comprising proteins or nucleic acids. The formation of these condensates requires …

Learning the chemical grammar of biomolecular condensates

HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …

A framework for understanding the functions of biomolecular condensates across scales

AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates

N Jaberi-Lashkari, B Lee, F Aryan, E Calo - Cell reports, 2023 - cell.com
Biomolecular condensates are implicated in core cellular processes such as gene
regulation and ribosome biogenesis. Although the architecture of biomolecular condensates …

[HTML][HTML] Principles and functions of condensate modifying drugs

A Patel, D Mitrea, V Namasivayam… - Frontiers in Molecular …, 2022 - frontiersin.org
Biomolecular condensates are compartmentalized communities of biomolecules, which
unlike traditional organelles, are not enclosed by membranes. Condensates play roles in …

Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics

BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …