Mitochondrial dysfunction in muscle has been implicated to play a causative role or being an
indirect consequence of insulin resistance in type-2 diabetes. In order to investigate …

Insulin plays pivotal role in cellular fuel metabolism in skeletal muscle. Despite being the
primary site of energy metabolism, the underlying mechanism on how insulin deficiency …

Introduction: Mitochondria are essential in energy metabolism and cellular survival, and
there is growing evidence that insulin resistance in chronic metabolic disorders, such as …

Hyperglycaemia-related mitochondrial impairment is suggested as a contributor to skeletal
muscle dysfunction. Aiming a better understanding of the molecular mechanisms that …

Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia
due to absolute or relative lack of insulin. Though great efforts have been made to …

Mitochondrial dysfunction is discussed as a key player in the pathogenesis of type 2
diabetes mellitus (T2Dm), a highly prevalent disease rapidly developing as one of the …

Type 2 diabetes results from the development of insulin resistance and a concomitant
impairment of insulin secretion. Mitochondrial dysfunctions are thought to be the major …

It has been proposed that mitochondrial dysfunction is involved in the pathogenesis of type 2
diabetes (T2D). To dissect the underlying mechanisms, we performed a multiplexed …

Reactive oxygen species resulting from diabetes mellitus contribute to damage and loss of
mitochondrial proteins. Two spatially distinct mitochondria populations exist in the cardiac …

The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with
mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome …