Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review

CS De Kloet, E Vermetten, E Geuze… - Journal of psychiatric …, 2006 - Elsevier
Posttraumatic stress disorder (PTSD) is typically accompanied by acute and chronic
alterations in the stress response. These alterations have mostly been described in …

Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder

R Yehuda, EL Giller, SM Southwick, MT Lowy… - Biological …, 1991 - Elsevier
Neuroendocrine studies examining the hypothalamic-pituitary-adrenal (HPA) axis under
baseline conditions and in response to neuroendocrine challenges have supported the …

Implications of hypothalamic–pituitary–adrenal axis functioning in posttraumatic stress disorder

T Jones, MD Moller - Journal of the American Psychiatric …, 2011 - journals.sagepub.com
Background: Cortisol secretions serve as the barometer of the hypothalamic–pituitary–
adrenal (HPA) axis, which regulates and controls responses to stress. Studies of cortisol …

Differential patterns of HPA activity and reactivity in adult posttraumatic stress disorder and major depressive disorder

K Handwerger - Harvard review of psychiatry, 2009 - journals.lww.com
Despite a number of overlapping symptoms, individuals with posttraumatic stress disorder
(PTSD) and major depressive disorder (MDD) often display hypothalamic‐pituitary‐adrenal …

Predicting PTSD prospectively based on prior trauma history and immediate biological responses

DL Delahanty, NR Nugent - Annals of the New York Academy …, 2006 - Wiley Online Library
Studies examining the biopsychology of posttraumatic stress disorder (PTSD) have
suggested that PTSD is characterized by alterations of the primary stress pathways: the …

Current status of cortisol findings in post-traumatic stress disorder

R Yehuda - Psychiatric Clinics, 2002 - psych.theclinics.com
The majority of studies of post-traumatic stress disorder (PTSD) demonstrate alterations
consistent with an enhanced negative feedback inhibition of cortisol on the pituitary and an …

Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: a meta-analysis

ER Klaassens, EJ Giltay, P Cuijpers, T van Veen… - …, 2012 - Elsevier
BACKGROUND: Hypothalamic–pituitary–adrenal (HPA)-axis dysregulation has
inconsistently been associated with posttraumatic stress disorder (PTSD). Yet, trauma …

Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse

JD Bremner, M Vythilingam, E Vermetten, J Adil… - …, 2003 - Elsevier
Preclinical studies show that animals with a history of chronic stress exposure have
increased hypothalamic-pituitary-adrenal (HPA) axis reactivity following reexposure to …

HPA-and HPT-axis alterations in chronic posttraumatic stress disorder

M Olff, Y Güzelcan, GJ de Vries, J Assies… - …, 2006 - Elsevier
Posttraumatic stress disorder (PTSD) has been associated with dysregulation of the
hypothalamus-pituitary-adrenal (HPA) axis as well as of the hypothalamus-pituitary-thyroid …

Neuroendocrine aspects of PTSD

R Yehuda - Anxiety and anxiolytic drugs, 2005 - Springer
This chapter discussed how neuroendocrine findings in posttraumatic stress disorder
(PTSD) potentially inform hypothalamic-pituitary-adrenal (HPA) alterations in PTSD and …