The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin …

The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Beta
(B. 1.351) and Gamma (P. 1) variants of concern (VoCs) include a key mutation (N501Y) …

Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19
pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has lasted
more than 2 years with over 260 million infections and 5 million deaths worldwide as of …

The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global health
crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral …

SARS-CoV-2 variants acquire mutations in spike that promote immune evasion and impact
other properties that contribute to viral fitness such as ACE2 receptor binding and cell entry …

Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …