Role of N6-methyl-adenosine modification in mammalian embryonic development

C Li, Z Jiang, J Hao, D Liu, H Hu, Y Gao… - Genetics and Molecular …, 2021 - SciELO Brasil
Abstract N6-methyl-adenosine (m6A) methylation is one of the most common and abundant
modifications of RNA molecules in eukaryotes. Although various biological roles of m6A …

RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Y Yue, J Liu, C He - Genes & development, 2015 - genesdev.cshlp.org
N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …

[HTML][HTML] Regulatory role of m6A epitranscriptomic modifications in normal development and congenital malformations during embryogenesis

Y Yao, P Liu, Y Li, W Wang, H Jia, Y Bai, Z Yuan… - Biomedicine & …, 2024 - Elsevier
The discovery of N6-methyladenosine (m 6 A) methylation and its role in translation has led
to the emergence of a new field of research. Despite accumulating evidence suggesting that …

Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals

M Zhang, Y Zhai, S Zhang, X Dai, Z Li - Frontiers in Cell and …, 2020 - frontiersin.org
N6-methyladenosine (m6A) is one of the most abundant internal mRNA modifications, and it
affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites …

The biogenesis and precise control of RNA m6A methylation

H Huang, H Weng, J Chen - Trends in Genetics, 2020 - cell.com
N 6-Methyladenosine (m 6 A) is the most prevalent internal RNA modification in mRNA, and
has been found to be highly conserved and hard-coded in mammals and other eukaryotic …

m6A RNA modification controls cell fate transition in mammalian embryonic stem cells

PJ Batista, B Molinie, J Wang, K Qu, J Zhang, L Li… - Cell stem cell, 2014 - cell.com
Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …

Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases

W Wei, X Ji, X Guo, S Ji - Journal of Cellular Biochemistry, 2017 - Wiley Online Library
ABSTRACT N6‐methyladenosine (m6A) modification is an abundant and conservative RNA
modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3 …

N6-Methyladenosine Methyltransferases and Demethylases: New Regulators of Stem Cell Pluripotency and Differentiation

Y Wu, S Zhang, Q Yuan - Stem Cells and Development, 2016 - liebertpub.com
The discovery of mammalian N 6-methyladenosine (m6A) methyltransferases and
demethylases has enriched our knowledge of the dynamic regulation of the most prevalent …

m6A RNA Modification Determines Cell Fate by Regulating mRNA Degradation

M Guo, X Liu, X Zheng, Y Huang, X Chen - Cellular reprogramming, 2017 - liebertpub.com
Emerging evidence suggests that epitranscriptional modifications influence multiple cellular
processes. N6-methyladenosine (m6A), as the most abundant reversible methylation of …

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

Y Wang, Y Li, JI Toth, MD Petroski, Z Zhang… - Nature cell …, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant internal
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …