Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

For decades, complement has been recognized as an effector arm of the immune system
that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

Background Mounting evidence suggests that complement components promote tumor
progression via modulating immune suppression, angiogenesis, or tumor cell proliferation …

Lung cancer is the leading cause of cancer death in men and women. Lung
adenocarcinoma (LUAD), represents approximately 40% of all lung cancer cases. Advances …

Metastatic behavior varies significantly among breast cancers. Mechanisms explaining why
the majority of breast cancer patients never develop metastatic outgrowth are largely lacking …

Constituent of innate immunity, complement is present in the tumor microenvironment. The
functions of complement include clearance of pathogens and maintenance of homeostasis …

The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer
(TNBC) patients is attributed to sparse or unresponsive tumor-infiltrating lymphocytes, but …