After injury or infection, neutrophils rapidly migrate from the circulation into tissues by means
of an orderly progression of adhesion receptor engagements. Neutrophils have been …

Objective: The objectives of this study were to 1) determine the time-course of T-lymphocyte
adhesion to monolayers of human umbilical vein endothelial cell (HUVEC) that were …

Mouse lymphocytes incubated on cryostat-cut sections of lymphoid organs (lymph nodes
and Peyer's patches) specifically adhere to the endothelium of high endothelial venules …

L-selectin mediates lymphocyte migration to peripheral lymph nodes and leukocyte rolling
on vascular endothelium during inflammation. One unique feature that distinguishes L …

Effective immunoprotection requires rapid recruitment of leukocytes into sites of surgery,
wounding, infection, or vaccination. In contrast to immunosuppressive chronic stressors …

Using lymphocyte function-associated antigen (LFA)-1−/− mice, we have examined the role
of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in …

Circulating lymphocytes leave the blood by binding to specialized high endothelial cells
lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating …

The first step in the migration of lymphocytes out of the blood is adherence of lymphocytes to
endothelial cells (EC) in the postcapillary venule. It is thought that in inflammatory reactions …

The leukocyte adhesion molecule L-selectin mediates neutrophil adhesive interactions with
endothelial cells and is in part responsible for neutrophil rolling. We examined the role of L …

To differentiate the unique and overlapping functions of LFA-1 and Mac-1, LFA-1-deficient
mice were developed by targeted homologous recombination in embryonic stem cells, and …