Highlights•Schizophrenia is highly polygenic with much missing heritability.•New statistical
tools are tailored to polygenic investigation of GWAS data.•Extensive enrichment is present …

After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …

Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …

Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …

Statistical genetics is a research field that focuses on mathematical models and statistical
inference methodologies that relate genetic variations (ie, naturally occurring human DNA …

The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …

Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …

Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci
associated with schizophrenia. However, a gap exists between the detection of genetic …

Schizophrenia is a devastating mental disorder. The level of risk in the general population is
sustained by the persistence of social, environmental and biological factors, as well as their …

The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …