Where are the missing pieces of the schizophrenia genetics puzzle?
On the basis of recent data from candidate region/gene and genome-wide association
studies (GWAS) and their follow-up investigations, the number of genes potentially …
studies (GWAS) and their follow-up investigations, the number of genes potentially …
Molecular risk factors for schizophrenia
S Modai, N Shomron - Trends in molecular medicine, 2016 - cell.com
Schizophrenia (SZ) is a complex and strongly heritable mental disorder, which is also
associated with developmental–environmental triggers. As opposed to most diagnosable …
associated with developmental–environmental triggers. As opposed to most diagnosable …
The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges
Genome-wide association studies have transformed psychiatric genetics and provided novel
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …
[HTML][HTML] Association between polygenic risk for schizophrenia, neurocognition and social cognition across development
Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia
risk, providing methods for quantifying schizophrenia polygenic risk based on common …
risk, providing methods for quantifying schizophrenia polygenic risk based on common …
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia
The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified
hundreds of risk variants potentially implicated in the disease. Further, novel statistical …
hundreds of risk variants potentially implicated in the disease. Further, novel statistical …
A breakthrough in schizophrenia genetics
KS Kendler, MC O'Donovan - JAMA psychiatry, 2014 - jamanetwork.com
The effort to understandthe nature of the genetic risk for schizophrenia began more than 100
years ago. Since then, many studies have confirmed schizophrenia is strongly familial …
years ago. Since then, many studies have confirmed schizophrenia is strongly familial …
[HTML][HTML] Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations
The complex aetiology of schizophrenia is postulated to share components with other
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …
How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete
A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …
Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia
JJ McGrath, PB Mortensen, PM Visscher… - Schizophrenia …, 2013 - academic.oup.com
Epidemiologists and geneticists have tended to explore their respective domains
independently, and as a consequence, these fields have drifted apart. The aim of this article …
independently, and as a consequence, these fields have drifted apart. The aim of this article …
Schizophrenia genetics: progress, at last
JG Mulle - Current opinion in genetics & development, 2012 - Elsevier
The heritability of schizophrenia is well established, and has motivated the search for
genetic variation that contributes to susceptibility. Recent progress from both genome-wide …
genetic variation that contributes to susceptibility. Recent progress from both genome-wide …