Where are the missing pieces of the schizophrenia genetics puzzle?

SL Girard, L Xiong, PA Dion, GA Rouleau - Current opinion in genetics & …, 2011 - Elsevier
On the basis of recent data from candidate region/gene and genome-wide association
studies (GWAS) and their follow-up investigations, the number of genes potentially …

Molecular risk factors for schizophrenia

S Modai, N Shomron - Trends in molecular medicine, 2016 - cell.com
Schizophrenia (SZ) is a complex and strongly heritable mental disorder, which is also
associated with developmental–environmental triggers. As opposed to most diagnosable …

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges

OB Smeland, O Frei, CC Fan, A Shadrin… - Psychiatric …, 2019 - journals.lww.com
Genome-wide association studies have transformed psychiatric genetics and provided novel
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …

[HTML][HTML] Association between polygenic risk for schizophrenia, neurocognition and social cognition across development

L Germine, EB Robinson, JW Smoller… - Translational …, 2016 - nature.com
Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia
risk, providing methods for quantifying schizophrenia polygenic risk based on common …

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia

A Devor, OA Andreassen, Y Wang… - Molecular …, 2017 - nature.com
The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified
hundreds of risk variants potentially implicated in the disease. Further, novel statistical …

A breakthrough in schizophrenia genetics

KS Kendler, MC O'Donovan - JAMA psychiatry, 2014 - jamanetwork.com
The effort to understandthe nature of the genetic risk for schizophrenia began more than 100
years ago. Since then, many studies have confirmed schizophrenia is strongly familial …

[HTML][HTML] Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations

WR Reay, MJ Cairns - Translational psychiatry, 2020 - nature.com
The complex aetiology of schizophrenia is postulated to share components with other
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …

How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete

LE Duncan, M Ostacher, J Ballon - Neuropsychopharmacology, 2019 - nature.com
A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …

Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia

JJ McGrath, PB Mortensen, PM Visscher… - Schizophrenia …, 2013 - academic.oup.com
Epidemiologists and geneticists have tended to explore their respective domains
independently, and as a consequence, these fields have drifted apart. The aim of this article …

Schizophrenia genetics: progress, at last

JG Mulle - Current opinion in genetics & development, 2012 - Elsevier
The heritability of schizophrenia is well established, and has motivated the search for
genetic variation that contributes to susceptibility. Recent progress from both genome-wide …