We have witnessed significant advances in the management of pulmonary arterial
hypertension (PAH)(1), a rare and severe condition characterized by intense pulmonary …

Pulmonary arterial hypertension (PAH) is a rare disorder characterized by progressive
obliteration of the pulmonary microvasculature that results in elevated pulmonary vascular …

Abstract Pulmonary Arterial Hypertension (PAH) is the progressive increase in mean
pulmonary arterial pressure (mPAP)(≥ 20 mmHg at rest). Current treatment strategies …

Aims Although right ventricular (RV) function is an important determinant of morbidity and
mortality in patients with pulmonary arterial hypertension (PAH), there is no treatment …

Pulmonary arterial hypertension (PAH) is a rare but frequently fatal condition marked by
vasoconstriction and vascular remodeling within small pulmonary arteries. The pathobiology …

The pathogenesis of pulmonary arterial hypertension (PAH) is complex, involving multiple
modulating genes and environmental factors. Multifactorial impairment of the physiologic …

Pulmonary arterial hypertension (PAH) describes a group of conditions with a common
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …

Pulmonary hypertension (PH) is clinically divided into 5 major types, characterized by
elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) …

It is well established that the endothelin, nitric oxide and prostacyclin pathways play an
important role in the development of pulmonary arterial hypertension (PAH). Indeed, the …

Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on
case reports and small series, and was largely ineffectual. As a deeper understanding of the …