Treatment of pulmonary arterial hypertension: recent progress and a look to the future

M Humbert, O Sitbon, C Guignabert… - The Lancet …, 2023 - thelancet.com
Pulmonary arterial hypertension (PAH) is a severe but treatable form of pre-capillary
pulmonary hypertension caused by pulmonary vascular remodelling. As a result of basic …

The role of chemokines and chemokine receptors in pulmonary arterial hypertension

A Mamazhakypov, G Viswanathan… - British Journal of …, 2021 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery
remodelling leading to increased right ventricular pressure overload, which results in right …

Therapy for pulmonary arterial hypertension: Glance on nitric oxide pathway

A Tettey, Y Jiang, X Li, Y Li - Frontiers in pharmacology, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe disease with a resultant increase of the
mean pulmonary arterial pressure, right ventricular hypertrophy and eventual death …

Clinical trial design and new therapies for pulmonary arterial hypertension

O Sitbon, M Gomberg-Maitland… - European …, 2019 - Eur Respiratory Soc
Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on
case reports and small series, and was largely ineffectual. As a deeper understanding of the …

[HTML][HTML] Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model

FAN Yong, HAO Yanjie, GAO Dai, GAO Lan… - Physiological …, 2021 - ncbi.nlm.nih.gov
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by vascular
remodeling and chronic inflammation. Macrophages are the key orchestrators of …

Advances in therapeutic interventions for patients with pulmonary arterial hypertension

M Humbert, EMT Lau, D Montani, X Jaïs, O Sitbon… - Circulation, 2014 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a disease characterized by progressive
remodeling of the distal pulmonary arteries, resulting in the loss of vascular cross-sectional …

New horizons in pulmonary arterial hypertension therapies

N Galiè, AH Ghofrani - European Respiratory Review, 2013 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a fatal disease associated with vasoconstriction
and vascular remodelling. There are three well-known pathways that contribute to the …

Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension

M Vaillancourt, G Ruffenach, J Meloche… - Canadian Journal of …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is characterized by remodelling of pulmonary
arteries caused by a proliferation/apoptosis imbalance within the vascular wall. This …

Animal models of pulmonary hypertension: Getting to the heart of the problem

JP Dignam, TE Scott, BK Kemp‐Harper… - British Journal of …, 2022 - Wiley Online Library
Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease
due to the development of right ventricular (RV) failure. At present, no treatments targeted at …

Pulmonary arterial hypertension: new insights and new hope

KB Martin, JR Klinger, SIS Rounds - Respirology, 2006 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a devastating disorder characterized by abnormal
increased vasoconstriction and vascular remodelling. In this review we discuss the …