Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets
Pulmonary arterial hypertension (PAH) encompasses a group of clinical entities
characterized by sustained vasoconstriction and progressive vascular remodeling that act in …
characterized by sustained vasoconstriction and progressive vascular remodeling that act in …
Pulmonary arterial hypertension: new insights and new hope
KB Martin, JR Klinger, SIS Rounds - Respirology, 2006 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a devastating disorder characterized by abnormal
increased vasoconstriction and vascular remodelling. In this review we discuss the …
increased vasoconstriction and vascular remodelling. In this review we discuss the …
Targeted therapies in pulmonary arterial hypertension
D Montani, MC Chaumais, C Guignabert… - Pharmacology & …, 2014 - Elsevier
Pulmonary arterial hypertension (PAH) is a rare disorder characterized by progressive
obliteration of small pulmonary arteries that leads to elevated pulmonary arterial pressure …
obliteration of small pulmonary arteries that leads to elevated pulmonary arterial pressure …
Rodent models of PAH: are we there yet?
NR Bauer, TM Moore… - American Journal of …, 2007 - journals.physiology.org
A RECENT META-ANALYSIS of 16 clinical trials of prostacyclin analogs, endothelin receptor
antagonists, and phosphodiesterase type 5 inhibitors in severe pulmonary arterial …
antagonists, and phosphodiesterase type 5 inhibitors in severe pulmonary arterial …
Emerging concepts in the molecular basis of pulmonary arterial hypertension: part II: neurohormonal signaling contributes to the pulmonary vascular and right …
BA Maron, JA Leopold - Circulation, 2015 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is defined foremost by a distinct pulmonary vascular
pathophenotype that occurs as a result of dysregulated vascular cell proliferation, intimal …
pathophenotype that occurs as a result of dysregulated vascular cell proliferation, intimal …
Targeting Jak–Stat signaling in experimental pulmonary hypertension
D Yerabolu, A Weiss, B Kojonazarov… - American Journal of …, 2021 - atsjournals.org
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the
pulmonary vasculopathy including the obliteration of the lung vasculature that causes an …
pulmonary vasculopathy including the obliteration of the lung vasculature that causes an …
Molecular pathogenesis of pulmonary arterial hypertension
M Rabinovitch - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Recent investigations have suggested that it might be possible to reverse the pathology of
pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal …
pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal …
Pharmacologic treatments for pulmonary hypertension: exploring pharmacogenomics
JD Duarte, RL Hanson, RF Machado - Future cardiology, 2013 - Taylor & Francis
Pulmonary hypertension (PH) is a disease with multiple etiologies and is categorized into
five broad groups. Of these groups, pulmonary arterial hypertension (PAH) is the most …
five broad groups. Of these groups, pulmonary arterial hypertension (PAH) is the most …
Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension
Pulmonary hypertension (PH) is a devastating disease and its successful treatment remains
to be accomplished despite recent advances in pharmacotherapy. It has been proposed that …
to be accomplished despite recent advances in pharmacotherapy. It has been proposed that …
Emerging therapies for the treatment of pulmonary hypertension
KR Stenmark, M Rabinovitch - Pediatric Critical Care Medicine, 2010 - journals.lww.com
Current treatment of pulmonary arterial hypertension, which includes the use of
prostacyclins, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors …
prostacyclins, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors …