Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets

A Bourgeois, J Omura, K Habbout, S Bonnet… - The international journal …, 2018 - Elsevier
Pulmonary arterial hypertension (PAH) encompasses a group of clinical entities
characterized by sustained vasoconstriction and progressive vascular remodeling that act in …

Pulmonary arterial hypertension: new insights and new hope

KB Martin, JR Klinger, SIS Rounds - Respirology, 2006 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a devastating disorder characterized by abnormal
increased vasoconstriction and vascular remodelling. In this review we discuss the …

Targeted therapies in pulmonary arterial hypertension

D Montani, MC Chaumais, C Guignabert… - Pharmacology & …, 2014 - Elsevier
Pulmonary arterial hypertension (PAH) is a rare disorder characterized by progressive
obliteration of small pulmonary arteries that leads to elevated pulmonary arterial pressure …

Rodent models of PAH: are we there yet?

NR Bauer, TM Moore… - American Journal of …, 2007 - journals.physiology.org
A RECENT META-ANALYSIS of 16 clinical trials of prostacyclin analogs, endothelin receptor
antagonists, and phosphodiesterase type 5 inhibitors in severe pulmonary arterial …

Emerging concepts in the molecular basis of pulmonary arterial hypertension: part II: neurohormonal signaling contributes to the pulmonary vascular and right …

BA Maron, JA Leopold - Circulation, 2015 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is defined foremost by a distinct pulmonary vascular
pathophenotype that occurs as a result of dysregulated vascular cell proliferation, intimal …

Targeting Jak–Stat signaling in experimental pulmonary hypertension

D Yerabolu, A Weiss, B Kojonazarov… - American Journal of …, 2021 - atsjournals.org
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the
pulmonary vasculopathy including the obliteration of the lung vasculature that causes an …

Molecular pathogenesis of pulmonary arterial hypertension

M Rabinovitch - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Recent investigations have suggested that it might be possible to reverse the pathology of
pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal …

Pharmacologic treatments for pulmonary hypertension: exploring pharmacogenomics

JD Duarte, RL Hanson, RF Machado - Future cardiology, 2013 - Taylor & Francis
Pulmonary hypertension (PH) is a disease with multiple etiologies and is categorized into
five broad groups. Of these groups, pulmonary arterial hypertension (PAH) is the most …

Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension

RK Sharma, AC Oliveira, S Kim, K Rigatto… - …, 2018 - Am Heart Assoc
Pulmonary hypertension (PH) is a devastating disease and its successful treatment remains
to be accomplished despite recent advances in pharmacotherapy. It has been proposed that …

Emerging therapies for the treatment of pulmonary hypertension

KR Stenmark, M Rabinovitch - Pediatric Critical Care Medicine, 2010 - journals.lww.com
Current treatment of pulmonary arterial hypertension, which includes the use of
prostacyclins, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors …