How valid are animal models to evaluate treatments for pulmonary hypertension?
ME Campian, M Hardziyenka, MC Michel… - … archives of pharmacology, 2006 - Springer
Various animal models of pulmonary hypertension (PH) exist, among which injection of
monocrotaline (MCT) and exposure to hypoxia are used most frequently. These animal …
monocrotaline (MCT) and exposure to hypoxia are used most frequently. These animal …
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats
R Dumitrascu, C Kulcke, M Königshoff… - European …, 2011 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterised by
vasoconstriction and remodelling of the pulmonary vasculature. The serotonin (5 …
vasoconstriction and remodelling of the pulmonary vasculature. The serotonin (5 …
Therapeutic targets in pulmonary arterial hypertension
CJ Rhodes, A Davidson, JSR Gibbs, J Wharton… - Pharmacology & …, 2009 - Elsevier
Pulmonary arterial hypertension is a progressive, fatal disease. Current treatments including
prostanoids, endothelin-1 (ET-1) antagonists, and phosphodiesterase (PDE) inhibitors, have …
prostanoids, endothelin-1 (ET-1) antagonists, and phosphodiesterase (PDE) inhibitors, have …
[HTML][HTML] Molecular pathogenesis of pulmonary arterial hypertension
M Rabinovitch - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …
Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats
LC Price, D Montani, C Tcherakian… - European …, 2011 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is associated with dysregulated bone morphogenetic
protein receptor (BMPR)-II signaling and pulmonary vascular inflammation. We evaluated …
protein receptor (BMPR)-II signaling and pulmonary vascular inflammation. We evaluated …
A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
J Gomez-Arroyo, SJ Saleem… - … of Physiology-Lung …, 2012 - journals.physiology.org
Many chronic pulmonary diseases are associated with pulmonary hypertension (PH) and
pulmonary vascular remodeling, which is a term that continues to be used to describe a wide …
pulmonary vascular remodeling, which is a term that continues to be used to describe a wide …