Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability …
CH Li, MK Shyu, C Jhan, YW Cheng… - Toxicological …, 2015 - academic.oup.com
Abstract Gold nanoparticles (Au-NPs) are being increasingly used as constituents in
cosmetics, biosensors, bioimaging, photothermal therapy, and targeted drug delivery. This …
cosmetics, biosensors, bioimaging, photothermal therapy, and targeted drug delivery. This …
Gold nanoparticles compromise TNF-α-induced endothelial cell adhesion molecule expression through NF-κB and protein degradation pathways and reduce …
The aim of this study was to investigate the anti-inflammatory effects and mechanism of
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …
Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells
Y Liu, N Rogel, K Harada, L Jarett, CH Maiorana… - …, 2017 - Taylor & Francis
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …
Uptake of gold nanoparticles in primary human endothelial cells
Gold nanoparticles (AuNPs) are relevant in nanomedicine for drug delivery in the vascular
system, where endothelial cells are the first point of contact. We investigated the uptake of …
system, where endothelial cells are the first point of contact. We investigated the uptake of …
Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability
WJ Trickler, SM Lantz, RC Murdock, AM Schrand… - …, 2011 - Taylor & Francis
This report examined blood-brain barrier (BBB) related proinflammatory mediators and
permeability changes in response to various sized gold nanoparticles (Au-NPs)(3, 5, 7, 10 …
permeability changes in response to various sized gold nanoparticles (Au-NPs)(3, 5, 7, 10 …
Gold nanoparticle interactions with endothelial cells cultured under physiological conditions
C Freese, L Anspach, RC Deller, SJ Richards… - Biomaterials …, 2017 - pubs.rsc.org
PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous
injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and …
injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and …
Gold nanoparticles induced endothelial leakiness depends on particle size and endothelial cell origin
The endothelium presents a formidable barrier for cancer nanomedicine, as the
intravenously introduced nanomedicine needs to leave the blood vessel at the tumor site …
intravenously introduced nanomedicine needs to leave the blood vessel at the tumor site …
Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model
L Xu, M Dan, A Shao, X Cheng, C Zhang… - International journal …, 2015 - Taylor & Francis
Background Silver nanoparticles (Ag-NPs) can enter the brain and induce neurotoxicity.
However, the toxicity of Ag-NPs on the blood–brain barrier (BBB) and the underlying …
However, the toxicity of Ag-NPs on the blood–brain barrier (BBB) and the underlying …
Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial …
T Mohamed, S Matou-Nasri, A Farooq… - International journal …, 2017 - Taylor & Francis
Background Gold nanoparticles (AuNPs) demonstrate clinical potential for drug delivery and
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …
Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time
Gold nanoparticles (AuNPs) are used in many applications; however, their interactions with
cells and potential health risk (s) are not fully known. In this manuscript, we describe the …
cells and potential health risk (s) are not fully known. In this manuscript, we describe the …
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