Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability …

CH Li, MK Shyu, C Jhan, YW Cheng… - Toxicological …, 2015 - academic.oup.com
Abstract Gold nanoparticles (Au-NPs) are being increasingly used as constituents in
cosmetics, biosensors, bioimaging, photothermal therapy, and targeted drug delivery. This …

Gold nanoparticles compromise TNF-α-induced endothelial cell adhesion molecule expression through NF-κB and protein degradation pathways and reduce …

TH Lai, CH Chung, BH Chen, CF Hung… - Journal of …, 2016 - ingentaconnect.com
The aim of this study was to investigate the anti-inflammatory effects and mechanism of
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …

Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells

Y Liu, N Rogel, K Harada, L Jarett, CH Maiorana… - …, 2017 - Taylor & Francis
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …

Uptake of gold nanoparticles in primary human endothelial cells

H Klingberg, LB Oddershede, K Loeschner… - Toxicology …, 2015 - academic.oup.com
Gold nanoparticles (AuNPs) are relevant in nanomedicine for drug delivery in the vascular
system, where endothelial cells are the first point of contact. We investigated the uptake of …

Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability

WJ Trickler, SM Lantz, RC Murdock, AM Schrand… - …, 2011 - Taylor & Francis
This report examined blood-brain barrier (BBB) related proinflammatory mediators and
permeability changes in response to various sized gold nanoparticles (Au-NPs)(3, 5, 7, 10 …

Gold nanoparticle interactions with endothelial cells cultured under physiological conditions

C Freese, L Anspach, RC Deller, SJ Richards… - Biomaterials …, 2017 - pubs.rsc.org
PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous
injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and …

Gold nanoparticles induced endothelial leakiness depends on particle size and endothelial cell origin

MI Setyawati, CY Tay, BH Bay, DT Leong - ACS nano, 2017 - ACS Publications
The endothelium presents a formidable barrier for cancer nanomedicine, as the
intravenously introduced nanomedicine needs to leave the blood vessel at the tumor site …

Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model

L Xu, M Dan, A Shao, X Cheng, C Zhang… - International journal …, 2015 - Taylor & Francis
Background Silver nanoparticles (Ag-NPs) can enter the brain and induce neurotoxicity.
However, the toxicity of Ag-NPs on the blood–brain barrier (BBB) and the underlying …

Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial …

T Mohamed, S Matou-Nasri, A Farooq… - International journal …, 2017 - Taylor & Francis
Background Gold nanoparticles (AuNPs) demonstrate clinical potential for drug delivery and
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …

Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time

T Mironava, M Hadjiargyrou, M Simon… - …, 2010 - Taylor & Francis
Gold nanoparticles (AuNPs) are used in many applications; however, their interactions with
cells and potential health risk (s) are not fully known. In this manuscript, we describe the …