Effects of host‐directed therapies on the pathology of tuberculosis

L Tsenova, A Singhal - The Journal of pathology, 2020 - Wiley Online Library
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has co‐evolved with
the human immune system and utilizes multiple strategies to persist within infected cells, to …

Host-directed therapeutic strategies for tuberculosis

A Kolloli, S Subbian - Frontiers in medicine, 2017 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of
morbidity and mortality in humans worldwide. Currently, the standard treatment for TB …

Host-directed therapeutics as a novel approach for tuberculosis treatment

YR Kim, CS Yang - Journal of microbiology and …, 2017 - repository.hanyang.ac.kr
Despite significant efforts to improve the treatment of tuberculosis (TB), it remains a
prevalent infectious disease worldwide owing to the limitations of current TB therapeutic …

Host-directed therapies for tuberculosis

EK Jeong, HJ Lee, YJ Jung - Pathogens, 2022 - mdpi.com
Tuberculosis (TB) is one of the leading causes of death worldwide, consistently threatening
public health. Conventional tuberculosis treatment requires a long-term treatment regimen …

[HTML][HTML] Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies

D Tiwari, AR Martineau - Seminars in Immunology, 2023 - Elsevier
Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Host directed therapies for tuberculosis: futures strategies for an ancient disease

I Palucci, G Delogu - Chemotherapy, 2018 - karger.com
The emergence and spread of drug-resistant strains of Mycobacterium tuberculosis is
worsening the global threat of tuberculosis (TB). There is a need and urgency for the …

Host-directed therapies: modulating inflammation to treat tuberculosis

S Krug, S Parveen, WR Bishai - Frontiers in immunology, 2021 - frontiersin.org
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Remembering the host in tuberculosis drug development

DJ Frank, DJ Horne, NK Dutta, MT Shaku… - The Journal of …, 2019 - academic.oup.com
New therapeutics to augment current approaches and shorten treatment duration are of
critical importance for combating tuberculosis (TB), especially those with novel mechanisms …

Host-directed therapy as a novel treatment strategy to overcome tuberculosis: targeting immune modulation

S Ahmed, R Raqib, GH Guðmundsson, P Bergman… - Antibiotics, 2020 - mdpi.com
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in
developing countries, presenting a major threat to the public health. The currently …

Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs

JM Cubillos-Angulo, BMF Nogueira, MB Arriaga… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by
an infectious disease worldwide. It can also result in significant morbidity related to …