We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Males and females may respond differently to medications, yet knowledge about sexual
dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study …

Polypharmacy (use of≥ 5 medications) and increasing Drug Burden Index (DBI) score
(measure of person's total exposure to anticholinergic/sedative medications) are associated …

A major challenge in the health care system is the lack of knowledge about the possible
harmful effects of multiple drug treatments in old age. The present study aims to characterize …

Background: Little information is available on the potential association between
polypharmacy and risk of mortality. Objective: To determine in a population-based study …

Aging and multimorbidity are associated with inflammation. Polypharmacy is common in
older people with multimorbidity. Given the potential for interactions between polypharmacy …

Background: To investigate the association of polypharmacy with physical function,
nutritional status, and depression in the elderly. Method: The study included 675 people …

Background. Numerous methods have been used to evaluate medication management
quality in older adults; however, their predictive validities are unknown. Major medication …

Geriatric Cognitive Decline and Polypharmacy - Abstract - Europe PMC Sign in | Create an
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The World Health Organization estimates that worldwide, the proportion of older people in
the total population is increasing at more than 3 times the overall population growth rate …