In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …

Folates play a key role in one-carbon metabolism essential for the biosynthesis of purines,
thymidylate and hence DNA replication. The antifolate methotrexate has been rationally …

This review summarizes the biology of the major facilitative membrane transporters, the
reduced folate carrier (RFC)(Solute Carrier 19A1) and the proton-coupled folate transporter …

Folic acid is a water-soluble vitamin associated with the other B vitamins. In its fully reduced
form (tetrahydrofolate), folate serves as a 1-carbon donor for synthesis of purines and …

Most antifolate drugs are efficiently transported by the reduced-folate carrier (RFC).
However, several also bind with high affinity to the α-isoform of the folate receptor (α-FR) …

The antifolates were the first class of antimetabolites to enter the clinics more than 50 years
ago. Over the following decades, a full understanding of their mechanisms of action and …

The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are
ubiquitously expressed in normal and malignant mammalian tissues and in human solid …

Antifolates, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have
been used over several decades for the treatment of cancer and inflammatory diseases …

This chapter focuses on the biology of the major facilitative membrane folate transporters,
the reduced folate carrier (RFC), and the proton-coupled folate transporter (PCFT). Folates …

Members of the ATP-binding cassette (ABC) transporters including P-glycoprotein
(Pgp/ABCB1), multidrug resistance proteins (MRPs/ABCC) as well as breast cancer …