Highlights•PEA is an anti-inflammatory and neuroprotective compound.•Pharmacological
tools are available to control PEA levels via FAAH and NAAA inhibition.•FAAH and NAAA …

Identifying points of control in inflammation is essential to discovering safe and effective
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …

The existence of acylethanolamides (AEs) in the mammalian brain has been known for
decades. Among AEs, palmitoylethanolamide (PEA) is abundant in the central nervous …

All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that hydrolyzes saturated
or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and …

N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the
class of the N-acylethanolamine phospolipids and was firstly isolated from soy lecithin, egg …

Although its presence in mammalian tissues has been known since the 1960s, N-palmitoyl-
ethanolamine (PEA) has emerged only recently among other bioactive N-acylethanolamines …

Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its
neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N …

Palmitoylethanolamide (PEA) is produced by mammalian cells from its biosynthetic
precursor, N-palmitoyl-phosphatidyl-ethanolamine, and inactivated by enzymatic hydrolysis …

N-palmitoylethanolamide (PEA) is a lipid mediator belonging to the class of the N-
acylethanolamine. Products containing PEA, also in ultramicronized formulation (um-PEA) …