Myostatin regulates both muscle mass and muscle metabolism. The myostatin null
(MSTN−/−) mouse has a hypermuscular phenotype owing to both hypertrophy and …

Myostatin also known as growth differentiation factor 8 (GDF‐8) has been of major interest in
the cachexia/sarcopenia/muscle wasting community since its discovery by McPherron et al …

Myostatin (MSTN), a member of the TGF-β superfamily, is a negative regulator of skeletal
muscle mass. We have previously shown that the cell survival/apoptosis pathway is a …

CONCLUSIONS This study resulted in the identification of 2000 genes whose expression
was affected by a lack of myostatin. A large proportion of the genes were involved in …

Myostatin [MSTN, also known as growth differentiation factor 8 (GDF8)], is an inhibitor of
skeletal muscle growth. Blockade of MSTN function has been reported to result in increased …

The natural aging process results in the physiological decline of multiple tissues and organ
systems. Changes commonly occur with middle age and include decreased skeletal muscle …

Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the
absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous …

Since its discovery, myostatin (MSTN) has been at the forefront of muscle therapy research
because intrinsic mutations or inhibition of this protein, by either pharmacological or genetic …

Muscle regeneration through myostatin inhibition : Current Opinion in Rheumatology Muscle
regeneration through myostatin inhibition : Current Opinion in Rheumatology Log in or Register …

We tested the hypothesis that increased muscle mass augments increases in bone strength
normally observed with exercise. Myostatin‐deficient mice, which show increased muscle …