Peripheral immune signatures in Alzheimer disease

D Goldeck, JM Witkowski, T Fülop… - Current Alzheimer …, 2016 - ingentaconnect.com
According to the current paradigm, the main cause of AD is the accumulation of neurotoxic
amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor …

Peripheral immune system in aging and Alzheimer's disease

W Cao, H Zheng - Molecular neurodegeneration, 2018 - Springer
Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …

Neuroinflammation, immune system and Alzheimer disease: searching for the missing link

F Guerriero, C Sgarlata, M Francis, N Maurizi… - Aging clinical and …, 2017 - Springer
Due to an increasingly aging population, Alzheimer disease (AD) represents a crucial issue
for the healthcare system because of its widespread prevalence and the burden of its care …

Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review

S Mahdiabadi, S Momtazmanesh, G Perry… - Reviews in the …, 2022 - degruyter.com
Abstract Alzheimer's disease (AD), the most common cause of dementia, is characterized by
progressive cognitive and memory impairment ensued from neuronal dysfunction and …

The impact of ageing on the CNS immune response in Alzheimer's disease

SEJ Chee, E Solito - Frontiers in Immunology, 2021 - frontiersin.org
Alzheimer's Disease (AD) is a progressive neurodegenerative disease strongly associated
with increasing age. Neuroinflammation and the accumulation of amyloid protein are …

Potential immunotargets for Alzheimer's disease treatment strategies

PL Fernández, GB Britton… - Journal of Alzheimer's …, 2013 - content.iospress.com
Alzheimer's disease (AD) exerts a profound burden on public health worldwide. AD etiology
is unknown, and research to understand its underlying pathology has produced agents for …

Innate immune system and inflammation in Alzheimer's disease: from pathogenesis to treatment

M Serpente, R Bonsi, E Scarpini… - Neuroimmunomodulation, 2014 - karger.com
Immune activation and inflammation, likely triggered by amyloid-beta (Aβ) deposition, play a
remarkable role in the pathogenesis of Alzheimer's disease (AD), which is the most frequent …

Neuroinflammation in Alzheimer's disease: friend or foe?

C Scuderi, R Facchinetti, L Steardo… - The FASEB …, 2020 - Wiley Online Library
Neuroinflammation is part of the complex immune response within the central nervous
system (CNS), whose details have been partially elucidated. The CNS immune response …

Neuroinflammation in Alzheimer's disease: from pathogenesis to a therapeutic target

SW Pimplikar - Journal of clinical immunology, 2014 - Springer
The top-down, reductionist approach of the past three decades has resulted in remarkable
progress in identifying genes and proteins involved in Alzheimer's disease (AD), including β …

Role of the peripheral innate immune system in the development of Alzheimer's disease

A Le Page, G Dupuis, EH Frost, A Larbi… - Experimental …, 2018 - Elsevier
Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact
cause of the disease is still not known although many scientists believe in the beta amyloid …