Mitochondria in early development: linking the microenvironment, metabolism and the epigenome
AJ Harvey - Reproduction, 2019 - rep.bioscientifica.com
Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …
Influence of maternal aging on mitochondrial heterogeneity, inheritance, and function in oocytes and preimplantation embryos
Contrasting the equal contribution of nuclear genetic material from maternal and paternal
sources to offspring, passage of mitochondria, and thus mitochondrial DNA (mtDNA), is …
sources to offspring, passage of mitochondria, and thus mitochondrial DNA (mtDNA), is …
Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence
J Van Blerkom - Reproduction, 2004 - rep.bioscientifica.com
Mitochondria are the most abundant organelles in the mammalian oocyte and early embryo.
While their role in ATP production has long been known, only recently has their contribution …
While their role in ATP production has long been known, only recently has their contribution …
The role of maternal mitochondria during oogenesis, fertilization and embryogenesis
JM Cummins - Reproductive BioMedicine Online, 2002 - Elsevier
This review examines the place of mitochondria in the life cycle through oogenesis,
ovulation and early embryogenesis. Mitochondria are semi-autonomous organelles …
ovulation and early embryogenesis. Mitochondria are semi-autonomous organelles …
The role of mitochondrial function in the oocyte and embryo
Mitochondria have long been known to be the powerhouses of the cell but they also
contribute to redox and Ca 2+ homeostasis, provide intermediary metabolites and store …
contribute to redox and Ca 2+ homeostasis, provide intermediary metabolites and store …
Oocyte mitochondria—Key regulators of oocyte function and potential therapeutic targets for improving fertility
The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …
production. This reliance on mitochondrial activity, together with the exclusively maternal …
Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells
J Van Blerkom - Reproductive biomedicine online, 2008 - Elsevier
In addition to their role in generating energy (ATP), other possible regulatory functions for
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …
Impaired mitochondrial function in the preimplantation embryo perturbs fetal and placental development in the mouse
SL Wakefield, M Lane, M Mitchell - Biology of reproduction, 2011 - academic.oup.com
The preimplantation embryo is sensitive to its environment and, despite having some
plasticity to adapt, environmental perturbations can impair embryo development, metabolic …
plasticity to adapt, environmental perturbations can impair embryo development, metabolic …
Mitochondrial function in the human oocyte and embryo and their role in developmental competence
J Van Blerkom - Mitochondrion, 2011 - Elsevier
The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …
and early embryogenesis is emerging from basic research in model species and from …
The role of mitochondria in the establishment of oocyte functional competence
JM Cummins - European Journal of Obstetrics & Gynecology and …, 2004 - Elsevier
Mitochondria are maternally inherited, semi-autonomous organelles with their own genomes
(mtDNA), largely responsible for the generation of energy in the form of cellular ATP …
(mtDNA), largely responsible for the generation of energy in the form of cellular ATP …