Oocyte mitochondrial function and reproduction

E Babayev, E Seli - Current Opinion in Obstetrics and Gynecology, 2015 - journals.lww.com
Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation window

Y Yue, L Ren, C Zhang, K Miao, K Tan… - Proceedings of the …, 2022 - National Acad Sciences
Mitochondrial remodeling during the peri-implantation stage is the hallmark event essential
for normal embryogenesis. Among the changes, enhanced oxidative phosphorylation is …

[HTML][HTML] Mitochondrial signal transduction

M Picard, OS Shirihai - Cell Metabolism, 2022 - cell.com
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

[HTML][HTML] Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential

E Fragouli, K Spath, S Alfarawati, F Kaper, A Craig… - PLoS …, 2015 - journals.plos.org
Mitochondria play a vital role in embryo development. They are the principal site of energy
production and have various other critical cellular functions. Despite the importance of this …

[HTML][HTML] Molecular machinery and pathophysiology of mitochondrial dynamics

YH Chiu, SCA Lin, CH Kuo, CJ Li - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondria are double-membraned organelles that exhibit fluidity. They are the main site
of cellular aerobic respiration, providing energy for cell proliferation, migration, and survival; …

The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights

GN Cecchino, E Seli, ELA da Motta… - Reproductive …, 2018 - Elsevier
Mitochondria have been implicated as key factors regulating female reproductive processes.
Notable progress has been made in determining the role of mitochondria with respect to …

Maintaining ancient organelles: mitochondrial biogenesis and maturation

RB Vega, JL Horton, DP Kelly - Circulation research, 2015 - Am Heart Assoc
The ultrastructure of the cardiac myocyte is remarkable for the high density of mitochondria
tightly packed between sarcomeres. This structural organization is designed to provide …

Transcriptional control of mitochondrial biogenesis and function

MB Hock, A Kralli - Annual review of physiology, 2009 - annualreviews.org
Mitochondria play central roles in energy homeostasis, metabolism, signaling, and
apoptosis. Accordingly, the abundance, morphology, and functional properties of …

Mitochondria: determinants of stem cell fate?

GC Parker, G Acsadi, CA Brenner - Stem cells and development, 2009 - liebertpub.com
Stem cells are traditionally classified as being either embryonic stem cells (ESCs) or somatic
stem cells. Such a designation has now become blurred by the advent of ostensibly …

[HTML][HTML] Mitochondria in health and diseases

S Javadov, AV Kozlov, AKS Camara - Cells, 2020 - mdpi.com
Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with
eukaryotic cells characteristics. They are the main source of ATP in the cell and play a …