Missense mutations in CACNA1A, the gene that encodes the pore-forming α1 subunit of
human voltage-gated CaV2. 1 (P/Q-type) calcium channels, cause a rare form of migraine …

Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-
gated CaV2. 1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a …

The pathophysiological mechanisms of migraine are not yet very well understood. The gene
CACNA1A, coding for the alpha 1A subunit of neuronal P/Q-type Ca2+ channels is mutated …

An increasing number of mutations in the CACNA1A gene have been identified, which are
associated with a broad clinical spectrum, including familial hemiplegic migraine …

Insights into the pathogenesis of migraine with aura may be gained from a study of human
CaV2. 1 channels containing mutations linked to familial hemiplegic migraine (FHM). Here …

Familial hemiplegic migraine (FHM)-causing mutations in the gene encoding the P/Q Ca2+
channel α1A subunit (CACNA1A) locate to the pore and voltage sensor regions and …

CaV2. 1 Ca2+ channels have a dominant and specific role in initiating fast synaptic
transmission at central excitatory synapses, through a close association between release …

Migraine is a very common disabling brain disorder with unclear pathogenesis. A subtype of
migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in …

Mutations in the CACNA1A gene that encodes the pore-forming α 1 subunit of human
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channels cause several autosomal-dominant …

Familial hemiplegic migraine (FHM) is a severe neurogenetic disorder for which three
causal genes, CACNA1A, SCN1A, and ATP1A2, have been implicated. However, more than …