The serum-free mouse embryo (SFME) cell line, derived in serum-free medium from 16-day-
old mouse embryos, exhibits unique properties. SFME cells grow indefinitely in culture …

The effects of leukemia inhibitory factor (LIF) on the differentiation and proliferation of
astrocyte progenitor cells in an enriched culture were studied. The astrocyte progenitor cells …

We have examined the ability of human astrocytes to synthesize and secrete leukemia
inhibitory factor (LIF), which is a multifunctional cytokine that controls cell proliferation and …

The differentiation of precursor cells into neurons or astrocytes in the developing brain has
been thought to be regulated in part by growth factors. We show here that neural precursors …

Serum-free mouse embryo (SFME) cells, derived in medium in which serum is replaced with
growth factors and other supplements, display distinctive properties:(i) SFME cells do not …

Previously we have shown that leukaemia inhibitory factor (LIF) potentiates the development
of murine spinal cord neurons in vitro, suggesting that it, or related factors, may play an …

The serum-free mouse embryo (SFME) cell line was isolated from 16-day-old Balb/c mouse
embryos in medium in which the usual serum supplement to the culture medium was …

Abstract: Growth inhibitory factor (GIF) is highly expressed in the CNS under physiological
conditions, but its expression is reduced in neurodegenerative diseases, such as …

Leukemia inhibitory factor (LIF) can regulate the survival and differentiation of certain
neurons and glial cells in culture. To determine the role of this cytokine in the central …

Leukemia inhibitory factor (LIF) is a cytokine involved in the survival, differentiation and
regeneration of sympathetic, sensory and motor neurons. Its effects in the brain are less well …