Background. The dysregulation of apoptosis may alter the progression of tumor growth and
explain the clinical dichotomy observed in children with neuroblastoma (NB). An …

Background. Neuroblastoma is a childhood tumor that often displays unusual biological
behavior. The tumor may present with widespread metastases that are unresponsive to …

Background/Purpose: Aggressive tumors may alter their expression of Bcl-2 proteins to
decrease apoptosis and increase survival. The authors reported previously that …

Spontaneous regression occurs in some cases of neuroblastoma, especially stage IVS. The
incidence of neuroblastoma has been reported to be increasing since the mass screening …

Bcl-2 protooncogene, originally discovered at the chromosomal breakpoint of the t (14; 18)
in follicular lymphoma, is known to regulate the process of programmed cell death or …

Apoptosis is the selective physiologic deletion of cells that are no longer required. Over‐
expression of the bcl‐2 protooncogene extends survival of neurons otherwise destined for …

Background. We have previously demonstrated an increase in hepatocyte apoptosis when
they are cocultured with neuroblastoma cells. Death receptors in the tumor necrosis factor …

Background/Purpose: Aggressive neuroblastomas avoid apoptosis and have increased
expression of the antiapoptotic protein, Bcl-2. Insulin-like growth factor-I (IGF-I) is mitogenic …

Neuroblastoma is the most common extracranial tumor of childhood. This tumor is
associated with alterations in apoptosis and is affected by various growth factors and …

Recent evidence suggests that resistance to antineoplastic therapy may result from
mutations in genes mediating the apoptotic response to DNA damage. To determine the …