OBJECTIVE—Obesity is associated with endocrine abnormalities that predict the
progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been …

Objective Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which
negatively regulates skeletal muscle mass. Recent animal studies suggest a role for …

Aim Some health benefits of exercise may be explained by an altered secretion of myokines.
Because previous focus has been on upregulated myokines, we screened for …

Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment
concepts need to be identified. Myostatin, a myokine known for restraining skeletal muscle …

Purpose There is mounting evidence that skeletal muscle produces and secretes
biologically active proteins or “myokines” that facilitate metabolic cross talk between organ …

Myostatin is a member of transforming growth factor-β superfamily that plays an important
inhibitory role during muscle development; in fact mutations of myostatin gene result in a …

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin is a member of the transforming growth factor-beta/bone morphogenetic protein
(TGF-β/BMP) super-family of secreted factors that functions as a potent inhibitor of skeletal …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …