[PDF][PDF] Cholesterol-phospholipid complexes in membranes

A Radhakrishnan, HM McConnell - Journal of the American …, 1999 - researchgate.net
One of the more resistant problems in structural biology has been to define the structure and
function of the liquid region of biological membranes. This is related to the fact that liquids …

Liquid-liquid immiscibility in membranes

HM McConnell, M Vrljic - Annual review of biophysics and …, 2003 - annualreviews.org
▪ Abstract The observation of liquid-liquid immiscibility in cholesterol-phospholipid mixtures
in monolayers and bilayers has opened a broad field of research into their physical …

Condensed complexes in vesicles containing cholesterol and phospholipids

A Radhakrishnan, H McConnell - Proceedings of the …, 2005 - National Acad Sciences
Animal cell membranes pose conceptual problems related to the physical chemistry of
liquids. An avenue to the solution of some of these problems has been opened by the …

[HTML][HTML] Condensed complexes of cholesterol and phospholipids

HM McConnell, A Radhakrishnan - Biochimica et Biophysica Acta (BBA) …, 2003 - Elsevier
There is overwhelming evidence that lipid bilayer regions of animal cell membranes are in a
liquid state. Quantitative models of these bilayer regions must then be models of liquids …

Condensed complexes of cholesterol and phospholipids

A Radhakrishnan, HM McConnell - Biophysical journal, 1999 - cell.com
Mixtures of dihydrocholesterol and phospholipids form immiscible liquids in monolayer
membranes at the air-water interface under specified conditions of temperature and 2 …

Saturated phospholipids with high melting temperatures form complexes with cholesterol in monolayers

SL Keller, A Radhakrishnan… - The Journal of Physical …, 2000 - ACS Publications
Many mixtures of phospholipids and cholesterol form immiscible liquid phases in a
monolayer at an air− water interface. As discovered recently, some binary mixtures of …

Cholesterol interacts with all of the lipid in bilayer membranes. Implications for models

MA Singer, L Finegold - Biophysical journal, 1990 - cell.com
The interaction of cholesterol with lipid membranes has been studied by differential
scanning calorimetry on liposomes, a technique which involves only the natural lipids, with …

Lipid phase transitions and mixtures

AG Lee - Membrane fluidity in biology, 1983 - books.google.com
The study of membranes takes the biochemist into very unfamiliar territory—the nature and
theory of mixtures. Mixtures are generally avoided in biochemistry as far as is possible, but …

Selective sterol-phospholipid associations in fluid bilayers

M Sugahara, M Uragami, SL Regen - Journal of the American …, 2002 - ACS Publications
The nearest-neighbor preferences of three exchangeable lipid monomers (two
phospholipids that differ in length, A and B, and a derivative of cholesterol, C) have been …

Semiempirical models for biomembrane phase transitions and phase separations

JA McCammon, JM Deutch - Journal of the American Chemical …, 1975 - ACS Publications
Experimental studies are reviewed to construct a model for the hydrocarbon chain
disordering in “fluid” phospho-lipid bilayers. Together with approximate expressions for the …