One strategy for deciphering inherited neurological disease is to examine the expression of
individual genes controlling the assembly and physiology of specific cell groups within the …

NEOCORTICAL neurons display a wide range of dendritic morphologies, ranging from
compact arborizations to highly elaborate branching patterns1. In vitro electrical recordings …

ALTHOUGH the idea of competition between nerve cells during development is hardly new,
it is enjoying a distict renaissance. There are several good reasons for this flurry of interest …

A remarkable feature of nerve cells is the complex and variable pattern of their axonal and
dendritic branches. Quantitative studies of a simple part of the nervous system in mammals …

THE failure of lesioned axons to regenerate over long distances in the mammalian central
nervous system (CNS) is not due to an inability of central neurons to regenerate, but rather …

IN humans, trauma to a peripheral nerve may be followed by chronic pain syndromes which
are only relieved by blockade of the effects of sympathetic impulse traffic1–4. It is presumed …

Single-gene mutations in mice initiate specific heritable neuronal diseases featuring
different patterns of epilepsy. Thirteen chromosomal loci for convulsive seizures and four loci …

Activity is thought to guide the patterning of synaptic connections in the developing nervous
system. Specifically, differences in the activity of converging inputs are thought to cause the …

Failure of normal brain development leads to mental retardation or autism in about 3% of
children. Many genes integral to pathways by which synaptic modification and the …

Manipulation of the cellular and hormonal environment of cultures of dissociated primary
neurones can be used to explore a neurone's developmental potential and to investigate the …