Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells

E Bonsergent, E Grisard, J Buchrieser… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs), including exosomes, are thought to mediate intercellular
communication through the transfer of cargoes from donor to acceptor cells. Occurrence of …

Content release of extracellular vesicles in a cell‐free extract

E Bonsergent, G Lavieu - Febs Letters, 2019 - Wiley Online Library
Extracellular vesicles (EV s) transfer molecules from donor to acceptor cells. The EV‐content
delivery process within the acceptor cell is poorly characterized. We developed a new cell …

Extracellular vesicle fusion visualized by cryo-electron microscopy

MI Morandi, P Busko, E Ozer-Partuk, S Khan… - PNAS …, 2022 - academic.oup.com
Extracellular vesicles (EVs) transfer bioactive molecules between cells in a process
reminiscent of enveloped viruses. EV cargo delivery is thought to occur by protein-mediated …

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

W Heusermann, J Hean, D Trojer, E Steib… - Journal of Cell …, 2016 - rupress.org
Exosomes are nanovesicles released by virtually all cells, which act as intercellular
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …

Routes and mechanisms of extracellular vesicle uptake

LA Mulcahy, RC Pink, DRF Carter - Journal of extracellular …, 2014 - Taylor & Francis
Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Extracellular vesicles: unique intercellular delivery vehicles

SLN Maas, XO Breakefield, AM Weaver - Trends in cell biology, 2017 - cell.com
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Differential fates of biomolecules delivered to target cells via extracellular vesicles

M Kanada, MH Bachmann, JW Hardy… - Proceedings of the …, 2015 - National Acad Sciences
Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …

Extracellular vesicles: composition, biological relevance, and methods of study

MŁP Zaborowski, L Balaj, XO Breakefield, CP Lai - Bioscience, 2015 - academic.oup.com
The release of extracellular vesicles (EVs), including exosomes and microvesicles, is a
phenomenon shared by many cell types as a means of communicating with other cells and …

[HTML][HTML] Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

HC Verdera, JJ Gitz-Francois, RM Schiffelers… - Journal of Controlled …, 2017 - Elsevier
Recent evidence has established that extracellular vesicles (EVs), including exosomes and
microvesicles, form an endogenous transport system through which biomolecules, including …

Extracellular vesicles: exosomes, microvesicles, and friends

G Raposo, W Stoorvogel - Journal of Cell Biology, 2013 - rupress.org
Cells release into the extracellular environment diverse types of membrane vesicles of
endosomal and plasma membrane origin called exosomes and microvesicles, respectively …