JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
R Sancho, AS Nateri, AG De Vinuesa, C Aguilera… - The EMBO …, 2009 - embopress.org
Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer.
We show here that the JNK MAP kinase pathway and one of its most important substrates …
We show here that the JNK MAP kinase pathway and one of its most important substrates …
[HTML][HTML] Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells
L Ouko, TR Ziegler, LH Gu, LM Eisenberg… - Journal of Biological …, 2004 - ASBMB
Wnts are morphogens with well recognized functions during embryogenesis. Aberrant Wnt
signaling has been demonstrated to be important in colorectal carcinogenesis. However, the …
signaling has been demonstrated to be important in colorectal carcinogenesis. However, the …
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
C Tong, Z Yin, Z Song, A Dockendorff, C Huang… - The American journal of …, 2007 - Elsevier
The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
From gut homeostasis to cancer
F Radtke, H Clevers, O Riccio - Current molecular medicine, 2006 - ingentaconnect.com
The mammalian intestine has one of the highest turnover rates in the body. The intestinal
epithelium is completely renewed in less than a week. It is divided into spatially distinct …
epithelium is completely renewed in less than a week. It is divided into spatially distinct …
c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/β-catenin signaling through GSK3β pathway
D Hu, W Fang, A Han, L Gallagher, RJ Davis… - …, 2008 - academic.oup.com
Increasing evidence shows that there is an interaction between mitogen-activated protein
kinase and Wnt signaling and that their interaction plays important roles in a variety of …
kinase and Wnt signaling and that their interaction plays important roles in a variety of …
[HTML][HTML] Caught in the Akt: regulation of Wnt signaling in the intestine
EC Anderson, MH Wong - Gastroenterology, 2010 - ncbi.nlm.nih.gov
There is a strong association between inflammation and initiation of cancer in a number of
organ systems. This correlation has been observed in patients with chronic inflammatory …
organ systems. This correlation has been observed in patients with chronic inflammatory …
Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1-and TCF-dependent mechanisms
EE Ibrahim, R Babaei-Jadidi, A Saadeddin… - Stem …, 2012 - academic.oup.com
Embryonic NANOG (NANOG 1) is considered as an important regulator of pluripotency while
NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG …
NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG …
[HTML][HTML] TNIK inhibition abrogates colorectal cancer stemness
M Masuda, Y Uno, N Ohbayashi, H Ohata… - Nature …, 2016 - nature.com
Canonical Wnt/β-catenin signalling is essential for maintaining intestinal stem cells, and its
constitutive activation has been implicated in colorectal carcinogenesis. We and others have …
constitutive activation has been implicated in colorectal carcinogenesis. We and others have …
[HTML][HTML] Wnt-reporter expression pattern in the mouse intestine during homeostasis
PS Davies, AD Dismuke, AE Powell, KH Carroll… - BMC …, 2008 - Springer
Abstract Background The canonical Wnt signaling pathway is a known regulator of cell
proliferation during development and maintenance of the intestinal epithelium. Perturbations …
proliferation during development and maintenance of the intestinal epithelium. Perturbations …
Wnt signalling in the mouse intestine
AR Clarke - Oncogene, 2006 - nature.com
Abstract The Apc Min/+ mouse has emerged as a powerful model of human intestinal tumour
predisposition. As such, it has provided a platform for studying genetic and epigenetic …
predisposition. As such, it has provided a platform for studying genetic and epigenetic …