Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer.
We show here that the JNK MAP kinase pathway and one of its most important substrates …

Wnts are morphogens with well recognized functions during embryogenesis. Aberrant Wnt
signaling has been demonstrated to be important in colorectal carcinogenesis. However, the …

The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …

The mammalian intestine has one of the highest turnover rates in the body. The intestinal
epithelium is completely renewed in less than a week. It is divided into spatially distinct …

Increasing evidence shows that there is an interaction between mitogen-activated protein
kinase and Wnt signaling and that their interaction plays important roles in a variety of …

There is a strong association between inflammation and initiation of cancer in a number of
organ systems. This correlation has been observed in patients with chronic inflammatory …

Embryonic NANOG (NANOG 1) is considered as an important regulator of pluripotency while
NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG …

Canonical Wnt/β-catenin signalling is essential for maintaining intestinal stem cells, and its
constitutive activation has been implicated in colorectal carcinogenesis. We and others have …

Abstract Background The canonical Wnt signaling pathway is a known regulator of cell
proliferation during development and maintenance of the intestinal epithelium. Perturbations …

Abstract The Apc Min/+ mouse has emerged as a powerful model of human intestinal tumour
predisposition. As such, it has provided a platform for studying genetic and epigenetic …