Determinants of immune complex-mediated glomerulonephritis. We have studied the
influence of steric factors on the clinico-pathologic expression of immune complex-mediated …

Nephritogenicity and the differential distribution of glomerular deposits as a function of
immunogen charge were examined in a murine model of chronic active serum sickness. A …

Affected patients are dependent on life-long hemodialysis or require kidney transplantation.
It is generally accepted that the pathogenesis of glomerulonephritis and glomerulosclerosis …

Glomerular injury, occurring either as primary glomerular disease or as part of a systemic
disease process, is usually a result of immune-mediated mechanisms. The morphologic …

Models of acute and chronic serum sickness in laboratory animals, used to elucidate
mechanisms of immune complex nephritis, have demonstrated that antigen-antibody …

In the present study in Munich-Wistar rats during the initial stages of autologous immune
complex nephritis (protein excretion 3 to 50 mg/24 hours) we examined the sequential …

I was delighted to be asked to act as guest editor for this special edition of Springer
Seminars in Immunopathology on the subject of Glomerulonephritis (GN), an area where …

Serial renal biopsies were performed in rabbits with acute and with chronic serum sickness
to determine the timing and extent of macrophage accumulation in the development of …

The immune system and the kidneys are closely linked. In health the kidneys contribute to
immune homeostasis, while components of the immune system mediate many acute forms …

The ultrastructural localization of immune complex (IC) and inflammatory mediator systems
in the glomerulus was investigated in active in situ IC glomerulonephritis employing …