In-silico screening of Acacia pennata and Bridelia retusa reveals pinocembrin-7-O-β-D-glucopyranoside as a promising β-lactamase inhibitor to combat antibiotic …

AK Umar, D Roy, M Abdalla, Y Modafer… - Journal of …, 2023 - Taylor & Francis
The β-lactamase of Pseudomonas aeruginosa is known to degrade β-lactam antibiotics
such as penicillins, cephalosporins, monobactams, and carbapenems. With the discovery of …

Insight into the screening of potential beta-lactamase inhibitors as anti-bacterial chemical agents through pharmacoinformatics study

P Parida, S Bhowmick, A Saha… - Journal of Biomolecular …, 2021 - Taylor & Francis
Drug resistance is an unsolved and major concern in the bacterial infection. Continuous
development of drug-resistance to the antibiotics exponentially rises the danger of bacterial …

In vitro and computational studies of the β-lactamase inhibition and β-lactam potentiating properties of plant secondary metabolites

B Kongkham, A Yadav, MD Ojha… - Journal of …, 2023 - Taylor & Francis
Abstract β-lactam resistance in bacteria is primarily mediated through the production of β-
lactamases. Among the several strategies explored to mitigate the issue of β-lactam …

Biochemical and molecular docking-based strategies of Acalypha indica and Boerhavia diffusa extract by targeting bacterial strains and cancer proteins

MSS Shimu, GK Paul, AK Dutta, C Kim… - Journal of …, 2023 - Taylor & Francis
Antibiotic-resistant microbes have emerged around the world, presenting a risk to health.
Plant-derived drugs have become a potential source for the production of antibiotic-resistant …

Identification of Phytochemicals with Inhibitory Potential Against Beta-lactamase Enzymes via Computer-aided Approach

GC Nwokebu, AB Adesina, CN Isibor, SA Aigbepue… - Bioorganic …, 2024 - Elsevier
Introduction Antibacterial drugs have been widely used for the past century to treat diseases,
but their efficacy has been limited by multi-resistant pathogens, particularly those that utilize …

Antibacterial and In Silico Evaluation of β-lactamase Inhibitory Potential of Pinus sylvestris L. (Scots Pine) Essential Oil

KA Oyewole, OO Oyedara, SH Awojide… - Proceedings of the …, 2023 - Springer
Antibiotic resistance remains one of the global challenges that needs urgent attention,
including finding alternative treatment options to conventional antibiotics and reversing …

Investigating the antibacterial mechanism of Ampelopsis cantoniensis extracts against methicillin-resistant Staphylococcus aureus via in vitro and in silico analysis

VNT Bich, TK Nguyen, TDT Thu, LTT Tran… - Journal of …, 2023 - Taylor & Francis
Methicillin-resistant Staphylococcus aureus (MRSA) is a critical pathogen responsible for a
wide variety of serious infectious diseases in humans. The accelerated phenomena of drug …

[HTML][HTML] In silico study of essential oil of Bambusa vulgaris leaves as an anti beta-lactamase compound

PW Anggini, SA Amanina, SR Asyura… - Molecular and Cellular …, 2022 - cellbiopharm.com
Background: Klebsiella pneumoniae is known as an extended spectrum beta (β)-lactamases
(ESBLs)-producing bacteria, which produces enzymes that cause resistance to β-lactam …

[HTML][HTML] Identification of natural inhibitor against L1 β-lactamase present in Stenotrophomonas maltophilia

D Jade, MA Harrison, S Sugumar - Journal of Molecular Modeling, 2022 - Springer
Antibiotic resistance is threatening the medical industry in treating microbial infections. Many
organisms are acquiring antibiotic resistance because of the continuous use of the same …

Enhancing bactericidal strategy with selected aromatic compounds: in vitro and in silico study

A Oztekin, K Karagoz, S Adem… - Journal of Biomolecular …, 2022 - Taylor & Francis
Abstract β-Lactamases are enzymes that catalyze the hydrolysis of the β-lactam ring,
resulting in loss of function in β-lactam antibiotics. In this report, the inhibition of β-lactamase …