The use of cisplatin, a chemotherapy drug, is often limited due to its renal side effects such
as acute kidney injury (AKI). However, there are no validated medications to prevent or treat …

Background Acute kidney injury (AKI) is one of the most common complications in clinic, but
there is still no effective treatment. Oridonin, extracted from Rabdosia rubescens, has been …

Ischemia–reperfusion injury (IRI) is the major cause of acute kidney injury (AKI). The
previous studies demonstrated that Oridonin can protect kidney against IRI-induced AKI, but …

Oxidative stress and inflammation are part and parcel of cisplatin‐induced nephrotoxicity.
The purpose of this work is to study the role of soy isoflavone constituent, daidzein, in …

Doxorubicin-mediated kidney impairment is a serious problem in cancer treatment.
Accordingly, this work investigated the ability of geraniol to modulate doxorubicin-induced …

Although cisplatin is a common drug in the treatment of malignant tumors, its clinical
application is limited due to various side effects, especially acute kidney injury (AKI). Till …

Oxidative stress and inflammation are considered to be the main pathogenesis of cisplatin
nephrotoxicity. Astilbin, a flavonoid with anti-oxidation and anti-inflammation function, has …

Oridonin exhibits a curative effect on liver carcinoma in patients and experimental animals.
In the present study, we performed proteomic and functional analyses to explore the …

Inflammation plays a pivotal role in the development and progression of diabetic
nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens …

Cisplatin is the most widely used chemotherapeutic agent. However, it often causes
nephrotoxicity, which results in acute kidney injury (AKI). Therefore, we urgently need a drug …